Observational studies on glucocorticoids are harmful!

Observational studies on glucocorticoids are harmful!

Correspondence to Professor Maarten Boers; [email protected] In this issue, Apostopoulos et al report yet another observational study on the association of glucocorticoid (GC) treatment with a bad outcome, in this case damage accrual in SLE. Unsurprisingly, the association is present, and ‘independent’ of potential confounders. Unsurprisingly, the authors argue for a causal relationship. So what is ne...

Correct sampling in observational studies.

This article has no abstract.

Are post-trial observational studies useful?

For more than two centuries, the measurement of urinary proteins has been a standard tool for nephrologists to diagnose kidney disease. Renal disease is characterized by changes in the glomerular filtration barrier leading to increased urinary excretion of proteins, the main protein of which is albumin. This was later called macroalbuminuria and appeared to be associated with an increased risk ...

Observational studies: why are they so important?

Replication studies considered harmful

Context: There is growing interest in establishing software engineering as an evidence-based discipline. To that end, replication is often used to gain confidence in empirical findings, as opposed to reproduction where the goal is showing the correctness, or validity of the published results. Objective: To consider what is required for a replication study to confirm the original experiment and ...